Polarization of macrophages: mechanisms, markers and factors of induction

Macrophages are key components of the innate immune system. The variability macrophage’s participation in tumor progression, determined by their functional polarization, opens up a wide prospect for modulating profile, primarily direction increasing antitumor activity. purpose study was to provide up-to-date data on process macrophage mechanisms its regulation, polarization markers and induction factors. Material methods . A search made available literature sources published Web Science, Scopus other databases. more than 160 devoted were found, which 121 included this review. Results This review presents molecular gene signatures associated with M1 M2 macrophages. We displayed information metabolic, phenotypic characteristics cytokine profile M1- M2-macrophages, as well highlighted factors targets action. Conclusion presented can serve an base development experimental clinical approaches editing macrophages order control involvement various pathological processes.